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Document 2921
DOCN M94A2921
TI Quality of life in people with depressive symptoms and HIV.
DT 9412
AU Rubin HC; Patterson TL; Atkinson JH; Kaplan RM; Koch WL; McCutchan JA;
Chandler JL; Grant I; UCSD.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):194 (abstract no. PB0205). Unique
Identifier : AIDSLINE ICA10/94369654
AB OBJECTIVES: To explore the impact of depressive symptoms on
health-related quality of life in people with HIV. METHODS: HIV+ (n =
285) and HIV- (n = 84) men participating in a longitudinal cohort study
were administered the Hamilton Depression Index (HAM-D) and the Quality
of Well Being Scale (QWB)--a general health-related outcome measure--at
baseline (T1) and six months later (T2). Clinically meaningful
depression was defined as HAM-D > or = 10; t-tests and ANOVA were used
to examine QWB scores in subgroups where in depression developed or
resolved on follow-up. RESULTS: At T1, there is a decline in QWB scores
among HIV+ subjects with increasing Hamilton scores (F = 21.60, p <
0.001). Among those HIV+ subjects who developed depressive symptoms from
T1 to T2 (n = 22), there was a decline in their QWB scores (t = 2.62, p
= 0.016). HIV subjects who had depressive symptoms at T1 which resolved
at T2 (n = 32), showed a rise in QWB scores (t = 2.00, p = 0.054). There
were no significant differences in QWB scores in the group that remained
depressed or in the group which remained symptom free between T1 and T2.
CONCLUSIONS: The QWB appears to be a valid measure of changes in quality
of life associated with depressive symptoms in HIV. Because of the
morbidity associated with depressive symptoms, identification and
treatment of mood symptoms and syndromes is an important priority.
DE Adaptation, Psychological Adult Cohort Studies Depression/*PSYCHOLOGY
Follow-Up Studies Human HIV Seronegativity HIV
Seropositivity/*PSYCHOLOGY Longitudinal Studies Male Personality
Inventory *Quality of Life *Sick Role MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).